Carlton R. Cooper, Ph.D.

UD - Biological Sciences

Assistant Professor
Department of Biological Sciences
University of Delaware
203 Wolf Hall
Newark DE 19716-2590

Phone: (302) 831-6062
FAX: (302) 831-2281
E-Mail: crcooper@udel.edu
Web Site: http://www.udel.edu/bio/people/faculty/ccooper.html

Education
Ph.D., Microbiology/Virology, Mississippi State University, 1998
M.S., Cell Biology, Clark Atlanta University, 1992
B.S., Biology, Morehouse College, 1989

Research Interests:
It is the preference of prostate cancer to spread (metastasize) to bone causing symptoms such as intense pain, bone fractures, and/or spinal cord compression. The molecular mechanisms for this metastatic pattern of advanced prostate cancer are not known and are under intense investigation. In order to metastasize to a particular organ, a cancer cell must first adhere to the endothelial cells lining the blood vessel (microvessel) that feeds the organ. Endothelial cells, derived from a specific organ’s microvessel, are distinct in their expression of cell adhesion molecules (CAMs). Previous studies have shown that prostate cancer cells adhered preferentially to human bone marrow endothelial cells (HBME) when compared to other endothelial cell types in vitro. This observation suggests that prostate cancer metastasis to bone is mediated partially by the preferential adhesion to HBME cells in the bone marrow.

The objective of my research is to identify the CAMs expressed on HBME cells inclusive of the respective ligands or counter-receptors found on prostate cancer cells that are involved in prostate cancer cell-HBME interaction. Once the CAM-ligand complex(es) responsible for prostate cancer cell adhesion to HBME cells is/are identified, the effect of bone-stromal factors on the expression of HBME-specific CAMs and prostate cancer- corresponding ligands will be examined. It is interesting to note that the activation of CAMs on prostate cancer cells by extracellular matrix components may contribute to the Akt (a kinase) activation of survival pathways and may allow the cancer cells to resist cytotoxic and hormonal therapies.

RECENT PRESS

Health experts to address issues in education, research, practice
January 26, 2012--DHSA will hold its inaugural Global Health Symposium on Saturday, Feb. 4 at CCHS. The program will focus on education, research and practice, with presentations on topics ranging from refugee health clinics and relief medicine to anthropological approaches to the study of global health.

Christiana Care issues a call to men to prevent domestic violence
January 24, 2012--Christiana Care, a National Community Center of Excellence in Women's Health, has been working for years to help women who are victims of domestic violence at an annual event that offers resources, education and support.

After Holiday Eating Marathon, Jefferson Dietitian Offers 10 Tips to Get Back on Track and Kick Start New Year's Weight Loss Resolution
January 4, 2012--Celebrating the New Year goes hand-in-hand with creating resolutions to get healthy and trim - especially after weeks of holiday marathon eating. Dietitian Emily Rubin, R.D., L.D., with the Division of Gastroenterology at Thomas Jefferson University Hospital, says you can stay committed to being healthy and fit by following these 10 tips.

Procedure saves teen after rare carotid trauma
January 4, 2012--Neurointerventionalist Gregg Zoarski, M.D.'s recent surgical grand rounds lecture on carotid artery injuries focused on how to repair traumatic injuries to these vital vessels that supply blood to the brain.

Medical students delighted with Delaware branch campus Christiana Care is participating in Jefferson Medical College�s Delaware Branch Campus program, underscoring the transformative role the health system plays in medical education.
December 23, 2011--This achievement specifically spotlights our core competency in providing clinical education to third- and fourth-year medical students. Christiana Care has a long-standing relationship in providing first-rate medical education to students from Jefferson, one of the country's top-rated medical collleges.

Healthy Kids Delaware (HKD) Network celebrated its one-year anniversary earlier this month.
December 22, 2011--Earlier this month the Healthy Kids Delaware (HKD) network celebrated its one-year anniversary. The Healthy Kids Delaware network has been working to address health and wellness needs of children throughout New Castle County.

Interprofessional Care for the 21st Century: Redefining Education and Practice
December 14, 2011--Registration is now open for Jefferson InterProfessional Education Center's (JCIPE) 2012 conference: Interprofessional Care for the 21st Century: Redefining Education and Practice. The conference will be held on May 18-19, 2012 at Dorrance H. Hamilton Building, Thomas Jefferson University, Philadelphia, PA. The purpose of this conference is to showcase scholarly work and works in progress advancing interprofessional education and/or practice. This conference reflects on innovative implementation and evaluation strategies of the interprofessional competencies.

Nemours participates in Partnership for a Healthier America Summit
December 8, 2011--The Partnership, of which Nemours is a founding member, has a mission of supporting First Lady Michelle Obama's Let's Move! campaign by working with the private sector to fight childhood obesity. The theme that emerged at the summit, a gathering of leaders from business and industry, academia, nonprofits and government, was: "Make the healthy choice the easy choice."

DHSA plans workshop on collaborative education for clinicians and scientists
December 8, 2011--DHSA will host "Creating Clinical and Research Teams for the Future: Workshop on Collaborative Education for Clinicians and Scientists" on Tuesday, Jan. 10, 2012, at the Ammon Education Center of Christiana Hospital. This workshop focuses on developing skills to write educational grants. The program will include information on how to obtain educational grant funding, set goals and evaluate an educational program, and develop an application for the DHSA Education Pilot Award.