Arthur M. Feldman, M.D., Ph.D.
Medical School
Louisiana State University, Shreveport, LA
Residency
The Johns Hopkins Hospital, Baltimore, M.D.
Fellowship
The Johns Hopkins Hospital, Baltimore, M.D.
Certifications
American Board of Internal Medicine, Subspecialty in Cardiovascular Diseases
University Appointment
Magee Professor of Medicine (with Tenure) 2002
Research and Clinical Interests
Our laboratory has focused for over two decades on the cellular signaling mechanisms that contribute to the development of heart muscle disease and heart failure. A longstanding interest has been the role of tumor necrosis factor in the development of the heart failure phenotype. More recently we have been studying the role of adenosine and adenosine receptor subtypes in the development of cardiac hypertrophy and failure. Studies focus on a group of novel transgenic mice that exhibit both constitutive and controlled over-expression of selective adenosine receptor sub-types as well as on mice with genetically altered signaling through the various G-protein-coupled and G-protein-regulated signaling pathways. A second major focus of the laboratory is to understand how polymorphisms in the genes encoding the various signaling proteins influence outcome and response to pharmacologic or surgical therapy in patients with heart failure. These studies include both polymorphism-specific association studies as well as genome wide studies using numerous genetic markers.
Publications
- Induced overexpression of Na+/Ca2+ exchanger transgene: Altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration
- Statin use is associated with improved survival in patients with advanced heart failure receiving resynchronization therapy
- 2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation.
- 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation.
- 2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults. A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation
- 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults. A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation
- Endothelial Nitric Oxide Synthase (NOS3) Polymorphisms in African Americans With Heart Failure: Results From the A-HeFT Trial
- Cardiac resynchronization therapy reduces the risk of hospitalizations in patients with advanced heart failure: results from the Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure (COMPANION) trial.
- TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model
- A Randomized Clinical Trial of the Clinical Effects of Enhanced Heart Failure Monitoring Using a Computer-Based Telephonic Monitoring System in Older Minorities and Women
- Regulation of cardiac myocyte contractility by phospholemman: Na +/Ca2+ exchange versus Na+-K+-ATPase
- Relationship of Inferior Vena Cava Filter Usage in Post-Surgical Patients by Various Surgical and Medical Subspecialists
- Impact of Cardiac Resynchronization Therapy on Exercise Performance, Functional Capacity, and Quality of Life in Systolic Heart Failure With QRS Prolongation: COMPANION Trial Sub-Study
- The rationale and design of the Surgical Treatment for Ischemic Heart Failure (STICH) trial
- The role of endomyocardial biopsy in the management of cardiovascular disease: A Scientific Statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology
- The Role of Endomyocardial Biopsy in the Management of Cardiovascular Disease. A Scientific Statement From the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology
- Low-dose oral enoximone enhances the ability to wean patients with ultra-advanced heart failure from intravenous inotropic support: Results of the oral enoximone in intravenous inotrope-dependent subjects trial
- Influence of Diabetes on Cardiac Resynchronization Therapy With or Without Defibrillator in Patients With Advanced Heart Failure
- The role of endomyocardial biopsy in the management of cardiovascular disease: A scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology
- Pharmacologic therapy of chronic heart failure