Christiana Care - Oncology
S. Eric Martin, M.D.
Clinical Investigator, Hematologic Oncology, Helen F Graham Cancer Center at Christiana Care
Active Staff Departments of Medicine and Pathology, Christiana Care
Academic Appointment:
Clinical Associate Professor of Medicine, Thomas Jefferson University
Education:
B.S - University of Puerto Rico - (1964-1968)
M.D. - University of Puerto Rico -(1968-1972)
Intern & Resident in Medicine, Rochester General Hospital (1972-1975)
Clinical Fellow in Hematology, Department of Medicine, University of Rochester School of Medicine & Dentistry (1975-1976)
Research Fellow in Hematology, Department of Medicine, University of Rochester School of Medicine & Dentistry (1976-1978)
Biography:
As a hematologic oncologist Dr. Martin is interested in the genetic changes that occur in individuals with a wide variety of cancers. Some of his research has centered around constructing a physical map of a loss of heterozygosity minimal region of loss on chromosome 11 associated with breast and lung cancer and subsequently cloning a hereditary translocation in a patient with early onset breast cancer and a family history of cancer. These results suggested that this locus may exert a tumor suppressor activity and is a likely target of the loss of heterozygosity on chromosome 11. Additional research has resulted in reporting a unique germline mutation in the BRCA1 gene in an individual of Asian /Filipino ancestry with early onset breast cancer and familial breast /ovarian cancer. The characteristics of the mutation, and the patient's loss of heterozygosity at the BRCA1 locus were reported as compatible with a mutation driven deleterious effect.